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Anti-inflammatory activities of purple sweet potato (Ipomoea batatas) and black carrot (Daucus carota ssp. sativa) in intestinal myofibroblast cells (CCD-18Co).

Author: Milenka Michelle León García (Ecuador)

Advisers: Jorge Cardona, Ph.D.

                     Juan Ruano, Ph.D.


Daily consumption of fruits and vegetables has become an important component of our diet. Consuming them in sufficient quantities and in a balanced way helps prevent various diseases such as diabetes, heart disease, cancer and micronutrient deficiencies.  The aim of this study was to determine the anti-inflammatory activity possessed by extracts of purple sweet potato and black carrot on intestinal myofibroblast cells (CCD-18Co).

An experimental design of randomized complete block factorial arrangement was used.  Treatments were four extracts (purple sweet potato, black carrot, and their hydrolyzed extracts) and three concentrations (10, 25 and 50 μg / ml).  Cell proliferation, reactive oxygen species and expression of various genes related to inflammation were evaluated.  Cell growth was not affected by the presence of extracts indicating that the extracts are specific to attacking inflammation and not normal cell development.  The effect on genes for the reduction of the expression of inflammation at the same concentration (25 μg / ml) was determined.  All extracts showed reduction in TNF-α, NF-KB, IL-6 and IL-1β gene activity.  For reactive oxygen species (ROS), all extracts reduced the generation of ROS.  The greatest reduction was found in hydrolyzed extracts from black carrot at concentrations 25 μg / ml and hydrolyzed extracts from purple sweet potato was independent for all hydrolyzed extracts.

This study demonstrated the anti-inflammatory capacity of purple sweet potato and black carrot as potential agents in the prevention of chronic diseases such as diabetes and cancer.

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Read the full research:  http://bdigital.zamorano.edu/bitstream/11036/3355/1/AGI-2014-019.pdf


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